Citing a “unprecedented risk” to life on Earth, prominent scientists, including Nobel laureates, have called for a worldwide freeze on the development of “mirror life” bacteria. According to a 299-page article and commentary published in Science, these artificial organisms, made from mirror-image molecules, could elude immune responses and result in fatal illnesses that are uncontrollable in humans, animals, and plants.
Mirror molecules, the structural opposites of natural biomolecules, are fascinating for their potential applications in medicine and industry. They could lead to innovative therapies for chronic diseases and enhance bioproduction by making facilities resistant to contamination. However, the risks associated with constructing whole organisms from these molecules have raised alarm among experts.
The DNA and proteins of all known life forms are built using asymmetrical molecules right-handed DNA nucleotides and left-handed amino acids. While scientists have successfully created large mirror molecules, building a complete mirror organism remains beyond current capabilities. However, with advancements, a viable mirror microbe could be possible within a decade.
Prof. Vaughn Cooper from the University of Pittsburgh warns that such microbes might bypass immune systems and spread unchecked. Existing antibiotics and natural predators would likely be ineffective against these organisms. The report advocates for a halt in funding and research until compelling evidence proves their safety.
The report, co-authored by scientists like Dr. Craig Venter and Prof. Greg Winter, emphasizes the importance of a global debate. Dr. Kate Adamala, a synthetic biologist who pivoted away from mirror cell research after assessing the risks, underscores the need for proactive discussion.
While some experts, like Prof. Paul Freemont of Imperial College London, acknowledge the potential benefits of mirror chemistry, they stress the necessity of strict regulations and responsible innovation.
“We must balance the promise of this technology with its extraordinary dangers,” the report concludes. The call aims to spark an international dialogue on the ethical and safety implications of mirror life research.